Sentence examples for mutation which accounts from inspiring English sources

The most common mutation, which accounts for 53% of HFI alleles identified worldwide, results in substitution of Pro for Ala at position 149.

Notably, the two PB1-F2 proteins, which were derived from the PR8 isolate and from the Spanish flu isolate, differ in amino acid 66, which is a Ser in IAVSF2 and an Arg in IAVPR8 (Fig. 1); this mutation, which accounts for the difference in pathogenicity [7], is within the mitochondrial targeting sequence [9].

We derive an effective migration rate experienced by the weakly beneficial mutation, which accounts for the reduction in gene flow imposed by linked selection.

Fgfr3 K652E and K652M mutations, which we described here, are found in human UCC but are much less frequent (3%) than the S249C mutation, which accounts for 67% of the FGFR3 mutations in bladder cancer (Knowles, 2008a).

More recent epidemiological studies suggested that missense mutation in the ATM gene, rather than a protein-truncating mutation, which accounts for the majority of mutations in patients with ataxia-telangiectasia, confers increased risk for breast cancer [ 10].

The most common mechanism of resistance is the EGFR T790M secondary mutation, which accounts for 50 60% of cases, and results in increased kinase affinity for adenosine triphosphate [18].

The drug was the first "personalised" treatment for melanoma, designed to target cases of the disease carrying the faulty gene, called a BRAF mutation, which account for about half of all cases.

Different studies have reported the response and outcome of CRCs to the anti-EGFR mAbs was poor with KRAS mutation which accounting for 30 40% of non-responsive cases.

This reanalysis enables us to estimate a spontaneous rate of SV mutations, which accounts for all mutations that are not single-base substitutions or short indels, in E. coli K-12 MG1655 of 0.00042 mutations per genome per generation (with a Poisson 95% confidence interval from 0.00032 0.00055).

We further identified three highly prevalent USP8 mutations, which account for the vast majority of mutated cases (77.61%).

However, the effects of missense mutations, which account for around 53% of IIN mutations, have not been investigated.