Sentence examples for mutation which eliminates from inspiring English sources

Cofactor oligonucleotides with a cytidine base at the 3′-end activatedvated a ribozyme with the G10.1·G11.1 mutation, which eliminates the cleavage activity in the wild-type.

The D114N mutation, which eliminates the negative charge of one of the putative Mg2+ ligands, also abolished phosphopantetheinylation activity of PptT.

Regarding apoE4, it is apparent that the N-terminal domain R61T mutation, which eliminates the putative interdomain R61 E255 salt bridge, has no effect on the amount of protein bound.

In agreement with our hypothesis, mutations which eliminated RNA binding also resulted in either exclusion of L22 from nucleoli or lack of retention of L22 in nucleoli (Fig. 6A: m88A m88andnd m80 93).

The development of a pro-tumour activity of TGFβ in tumour progression is often associated to mutations, which eliminate the tumour suppressor activities of TGFβ and promote growth and invasion.

One of the major advantages of TILLING is that it can not only identify null mutations which eliminate the function of the gene product entirely, but also missense alleles that result in a partial loss or change of gene function and which can allow disruption of specific domains within a gene and are especially useful for suppressor screens which can be used to identify interacting genes.

A second plasmid, p5-6m7C, identicalcal to p5-6C excepthatat it contains a 9-bp substitution mutation, m7, which eliminates the initiation bias in the two-ARS plasmid.

Most strikingly, when we introduced the A-site mutation (GGAAF)—which eliminates DGC activity into the chromosomal copy of ydaM, csgB::lacZ expression was not eliminated but was reduced only by ∼50%.

The new mutation operator is based on the four kinds of mutation operation in PGA, which eliminates the mutation probability.

The largest structural change occurs as a result of the D65V mutation (Fig. 5b), which eliminates the R21-D65 salt bridge, causing a significant repositioning of the Arg21 side chain.

Revertants have not experienced general mutagenesis and the yield of revertant colonies is unaffected by either a dinB (Quiñones-Soto and Roth 2011) or a lexA IND mutation (our unpublished results), which eliminates general mutagenesis and reduces revertant yield in the Cairns system (Slechta et al. 2003).