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This mutation involves a lysine to methionine substitution at position 29 and is present at a gene frequency of 30% in African populations [31] [33].

Nevertheless, analyzing the structure in detail, this residue is found exposed, and the mutation involves a charge inversion from a negatively charged glutamic acid to positively charged lysine.

The most common (>90%) second-site mutation involves a C→T change at nucleotide 2369 in exon 20, which results in substitution of methionine for threonine at position 790 (T790M).

This mutation involves a substitution of an aspartic acid (D) for the glycine (G) at the 13th position.

The K65R mutation involves a change at the second nucleotide codon position from lysine to arginine and causes intermediate-level resistance to tenofovir.

Interestingly, in rats the mutation involves a deletion of >5,000 base pairs whereas in cows there is a duplication of 76 base pairs.

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Similar(48)

But this mutation involves an amino acid exchange.

Some kinds of melanoma have a mutation involving a gene called BRAF; others don't.

The first mutation involved a deletion of an adenine in the OL at position 5182.

Moreover a combined mutation involving a membrane-bound protein and unknown soluble factors may be present.

Nineteen and 17 patients had a mutation involving a splice factor gene or an epigenetic regulator, respectively.

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