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The R120W mutation cancels a native restriction site for Ncil.
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Indeed, a LARG S1118D mutation cancelled the additional contribution of the LARG PH domain to nucleotide exchange, as did an E1023A mutation [ 23].
At mutation-selection balance the difference in selection coefficients among detrimental mutations cancels out and thus we may estimate load given a certain value of U [ 51].
Furthermore, crossing Fmr1 −/y and Tsc2 +/− mice produced a strain that is indistinguishable from wild type with regards to hippocampus-dependent synaptic plasticity and cognitive function, as the mutations cancelled one another out.
Conversely, if the mutations are either neutral or so deleterious as to have negligible fixation probability, as suggested by the neutral theory of molecular evolution (Kimura 1968, 1983), then the substitution rate would be relatively independent of population size, with the greater number of mutations cancelling the decreased probability of fixation.
He canceled a planned interview.
Senator Kelly Ayotte canceled a visit to Indiana.
Cancelled a world tour?
At first there was no sign for a natural; a sharp cancelled a flat, a flat cancelled a sharp.
I've had to cancel a meeting".
Washington cancelled a bilateral summit in September.
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