Sentence examples for mutation introduces a from inspiring English sources

When we follow one of the proposed mutations in [ 29], in which p27 is mutated and it is always off, the mutation introduces a situation where both CycD and Rb might be inactive.

The wnt2O mutation introduces a stop codon at residue Q40 likely producing a null mutant.

The fsn-1 hp1) fsn-1 hp1introduces a stop codon before the SPRY domutationsultintroducesrotein null allele.

Furthermore, in each case, the mutation introduces a large charged residue (Gly -> Arg in aldh1a2i26, Thr -> Lys in aldh1a2u11, Gly -> Arg in aldh1a2um22).

The GarsC201R mutation introduces a restriction site for the enzymes HaeII and HhaI, allowing us to genotype by PCR followed by RFLP analysis.

The Arg975Trp mutation introduces a large hydrophobic patch in H1' α-helix, whereas loss of Leu-954 provokes a distinct conformation of the extended coil.

If present, the mutation introduces an additional site at position 379 in the mutant eEF-2 gene.

The Ptk7 Chz mutation introduces an additional cleavage site for membrane type I matrix metalloproteinase, leading to instability of the cleaved ectodomain fragment (Golubkov et al., 2011).

The T → A transversion of the nonsense mutation introduces an AvrII restriction site and AvrII digestion of the PCR fragment results in fragmentation patterns which are indicative for the respective genotype of the tested animals.

However, the mutation introduces an additional positively charged arginine residue on the RNA-binding face of the deaminase domain very close to the active site and the DSH1 phenotype suggests that the ADAR1 G1007R protein may be catalytically inactive.

This point-mutant was generated by PCR using oligonucleotides carrying the Arg to Ala mutation in position 491 as well as a silent mutation introducing a BglII site to facilitate subcloning.