Sentence examples for mutation confers a from inspiring English sources

Thus, in HNPCC, in which a single further mutation confers a mutator phenotype, there is no increased risk of embryonal cancers, which require fewer oncogenic mutations in their formation, despite an increased colon cancer risk corresponding to the larger number of oncogenic mutations in the pathogenesis of colon cancer.

This mutation confers a poor prognosis in the metastatic setting, and a high risk of cancer recurrence as seen in several studies [6 9].

The triple mutation confers a three-fold increase in sensitivity to ciprofloxacin in vitro and similar sensitivities to a range of other quinolones.

(e) All mutations are 'equal' such that no mutation confers a survival advantage or disadvantage to the cell harboring it.

The observations made here with Rad21+/− mice indicate that one Rad21 allelic mutation confers a level of IR sensitivity that eclipses that observed in Atm heterozygous mice and accordingly raises the issue that should cancer patients with Rad21 or potentially other cohesin mutations be subjected to RT they may suffer adversely from standard RT protocols.

This mutation confers a higher degree of specificity to sialic acid residues that contain the human-like α-2,6 linkage [39], and it has allowed the H9N2-subtype virus to grow in human airway epithelial cells [40] and be directly transmitted in ferrets [34].

These data suggest that the PCHAS_031370 T719N mutation confers an increased CQ-R phenotype.

The V600E mutation confers an increase in BRAF kinase activity of approximately 480 times compared with wild-type BRAF, whereas the V600D mutation increases this by approximately 700 times (Wan et al, 2004).

In 1998, a second mutation conferring a congenital deficiency in leptin was described in three individuals from a consanguineous Turkish pedigree [15].

On the contrary, the Y143R mutation conferred a decreased sensitivity to RAL (FC = 2).

The presence of the plasma 249ser TP53 mutation conferred a statistically significant almost 4-fold increase in risk of cirrhosis in this population.