A woman with breast cancer who has a BRCA gene mutation has a four times greater risk of developing cancer in the other breast and a 10 times greater risk of ovarian cancer than does a woman with breast cancer who has no BRCA gene mutation.
Anyone with the mutation has a 50-80% chance of developing breast cancer.
Though S315 experiences large CSP upon specific RNA titration, the S315A mutation has a very small effect on the enzymatic activity.
The VP16 Inr element differs in sequence from that of the VP5 promoter, and its deletion or mutation has a significantly smaller effect on promoter strength.
The D23N mutation has a flat free-energy surface, corresponding to an increased population of random coil-like structures with weak hydrophobic and electrostatic interactions.
Indeed mathematical models show that a neutral allele arising by mutation has a very low probability of becoming fixed in a population; the larger the population, the lower the probability of fixation.
Her premonition was correct: a child whose parent has a BRCA2 mutation has a 50percentt chance of receiving it.
A woman with a BRCA mutation has a 50-85 percent lifetime risk of developing breast cancer, a 27percentt increased risk of developing ovarian cancer with a BRCA2 mutation, and as high as a 54percentt increased risk of ovarian cancer with a BRCA1 mutation.
In other words, an early giraffe might exhibit a longer neck, thanks to a random genetic mutation, and if this longer neck allows it to compete more successfully for food and mating rights, the new mutation has a chance, over time, to allow all giraffes to have longer necks.
As the Sleepless mutation has a high wake phenotype, these represent candidate regions for the mutation.
This conservative mutation has a highly similar structure to the WT CaB, yet at physiologic ionic strength its affinity to Ca2+ is reduced by ∼8 fold [22].
