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In summary, we have characterized a functional DAT mutant that encodes a tetraCys motif on the extracellular DAT domain EL2.

Although the loss of ATR alone does not impair telomere protection, it abolishes HOAP loading to telomeres in the atm mutant and exacerbates telomere uncapping in the atm atr double mutant to a degree similar to that in the single caravaggio (cav ) mutant that encodes a defective HOAP protein (Cenci et al. 2003; Bi et al. 2005; Rong 2008b).

To this end we constructed a MDJ1 truncation mutant that encodes a fragment lacking the C-terminal 321 amino acids, which after cleavage of the presequence upon entering the mitochondrial matrix, generates a 134 amino acid fragment having the J-domain at the N-terminus (Fig. 3A).

To test this possibility, we analyzed the effect of the leo1 mutant that encodes a component of the PAF complex that regulates elongation (Mbogning et al., 2013).

Similar(56)

For comparative purposes, the viruses analysed included the vSOCS mutants alongside wild-type MuHV-4 (vWT) and a previously described (Fowler et al, 2003) ORframeshifthift mutant (v73FS) that encodes only the 163 amino acids of the N-terminus of the protein.

For this purpose, we applied allele-specific polymerase chain reaction (PCR) to detect the FAS2-1250S domutant mutallelelele that encodes an altered fatty acid synthase in Japanese brewer's yeast strains.

Resistance to thyroid hormone (RTH) is a clinical syndrome in which most affected patients have a mutant TRβ allele that encodes a mutant receptor which has decreased binding affinity for T3 leading to decreased transcriptional activity [27].

We have constructed four mutant FMDVs that encode only one VPg: either VPg1, VPg3, or two chimeric versions containing part of VPg1 and VPg3.

For this purpose, we generated mutant mice with ES cell line PST080, harboring a mutant CD98hc allele that encodes a truncated form of CD98hc protein (ΔCD98hc) fused to β galactosidase and neomycin phosphotransferase II (β geo).

In lec1 and fus3 mutants, genes that encode markers of late embryogenesis are reduced or missing [ 9, 10].

We have reported isolation of a zebrafish mutant named to kto that encodes Mediator component Med12, also called Trap230 [6].

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