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The effective primer sets were not only specific for their target virus, but also able to detect multiple virus strains.
Current influenza vaccines should be improved by the addition of universal influenza vaccine antigens in order to protect against multiple virus strains.
Kong et al. (2008) reported transmission of multiple virus strains; Borderia et al. (2010) recently demonstrated a direct correlation between increasing genetic diversity and increasing in vivo viral fitness of clonal populations [47], [50].
This last scenario could be particularly problematic because many vaccines are multivalent, containing multiple virus strains.
To minimize this risk, multivalent vaccines are often comprised of multiple virus strains attenuated by common mutations.
Co-infection of the host with multiple virus strains could have evolutionary benefit to EBV, creating diversity through genetic recombination.
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Boosting with the full-length V3-CTB induced high anti-V3 titers in sera that potently neutralize multiple HIV virus strains.
Simultaneous infection with multiple influenza virus strains can affect virus fitness components, such as virus growth performance, and thus affect virus pathogenicity, transmission, or recombination (1 ).
Therefore, there is an urgent need for universal influenza vaccines (UIV) against multiple influenza virus strains, which could quickly and effectively prevent infections and lower transmissions of influenza viruses among human populations at early time.
PAR1 signalling inhibition decreases inflammation, early virus replication and mortality after infection with multiple influenza A virus strains, and is effective even when dosing was initiated at day 3 after inoculation.
In the longer term, more complex and realistic models of transmission of BTV are needed, which include separate transmission routes and seasonal vector dynamics, as well as multiple vector species and virus strains.
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