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Neutrophils play a pivotal role in the pathophysiology of multiple human inflammatory diseases.
Elevated MPO (myeloperoxidase) levels are associated with multiple human inflammatory pathologies.
Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases.
However, uncontrolled neutrophil recruitment or inappropriate neutrophil longevity is pathophysiologically involved in inflammatory diseases with unresolved neutrophilic inflammation and low levels of neutrophil apoptosis seen in multiple human inflammatory disease states.
NOD2 polymorphisms have been associated with multiple human inflammatory disorders, including Crohn's disease, Blau syndrome, early-onset sarcoidosis, and atopic diseases, which cause NF-κB constitutive activation [ 11, 85– 85].
These oxidants generated by both MPO [ 5], and other peroxidases (including salivary, gastric and eosinophil peroxidases; [ 1]) are important in the innate immune response against invading pathogens [ 2, 3], but have been implicated as damaging agents in multiple human inflammatory pathologies (reviewed in [ 1– 3]).
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Recently, accumulative evidences have revealed the PXR- and CAR-mediated herbal effect against multiple human diseases, including inflammatory bowel disease (IBD), cholestatic liver disease, and jaundice.
This distinct T helper cell lineage was discovered 5 years ago (Harrington et al, 2005) and have a prominent function in mucosal immunity and autoimmune diseases such as multiple sclerosis, as well as human inflammatory bowel disease and psoriasis.
Activation of inflammatory pathways in endothelial cells contributes to tumour growth and progression in multiple human cancers.
It has been recognised that IBP and the other 2-arylpropanoic acids have multiple human biological targets, as demonstrated by their numerous therapeutic applications, acting as analgesics and anti-inflammatories but also for treating neurodegenerative diseases and cancer.
Multiple human demonstrations must be "consistent".
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