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PTK6 is expressed in multiple human tumor types, including breast and ovarian tumors [14] [16], [18].
To compare the expression levels of TMEFF2 in human tissues, we analyzed Affymetrix microarray data obtained from GeneLogic, Inc. (Gaithersburg, MD) containing multiple human tumor and normal tissue samples.
Accordingly, inhibiting this signaling axis by the use of specific small molecule inhibitors of JAK2 has recently been investigated as a point of therapeutic intervention in multiple human tumor indications [3], [21], [22], [23], [24].
This includes multiple human tumor cell lines including glioblastoma, melanoma, ovarian carcinoma, prostatic carcinoma, and breast carcinomas).
Finally, multiple human tumor types show reduced SIRT4 levels (Csibi et al., 2013; Jeong et al., 2014).
CI-1040 blocks ERK phosphorylation and inhiblockshERKrowth of multiphosphorylation cell lines and tumor growth inhibitsraftheodels.
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Given the clinical relevance of maspin expression in a variety of epithelial tumors (including breast, prostate, lung and colon cancer), these studies describe a novel approach to target multiple human tumors [141 148].
TGF-β derived from cancer-associated fibroblasts upregulates CXCR4 in initiated prostatic epithelial cells [38], and expression of CXCR4 correlates with lymph node metastasis in multiple human tumors [39].
We recently demonstrated that HSF1 is highly expressed in multiple human tumors including lung, colon, breast, and ovarian cancers.
While the presence of CSCs has been documented in multiple human tumors, the mechanisms that regulate CSCs remain to be fully elucidated.
Overexpression of MDM2 is observed both in epithelial cells of transgenic mice with induced mammary carcinomas [ 4] and in multiple human tumors, including breast cancer [ 5- 7].
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multiple human tumours
multiple human inflammatory
multiple human papillomavirus
multiple human cytomegalovirus
multiple human liver
multiple human cell
multiple human tracking
multiple human tissue
multiple human interest
multiple intrinsic tumor
multiple human health
multiple concurrent tumor
multiple human brain
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