Exact(5)
Beneficial therapeutic effects of bromelain have been suggested or proven in several human inflammatory diseases and animal models of inflammation, including arthritis and inflammatory bowel disease.
We and others could detect Treg accumulation at sites of inflammation in several human inflammatory diseases [20], [21], a process potentially also initiated by cancer cells to attract Treg into human tumor tissue [25].
The human recombinant protein is currently being tested as a therapeutic agent in several human inflammatory diseases.
TGF- β can stimulate ROS production, which participates in the expression of diverse inflammatory genes such as MMPs in the processes of several human inflammatory diseases [ 100].
This can perpetuate inflammation leading to chronicity, with dysregulated granulocyte apoptosis being involved in the pathogenesis of several human inflammatory diseases.
Similar(55)
Moreover, S100A4 is found to be strongly up-regulated in several different human inflammatory disorders [ 41- 43].
Allelic polymorphisms of the ACP1 gene have been associated with susceptibility to several human diseases, including inflammatory and autoimmune diseases [ 5, 16].
These roles are reflected in the collagenase-mediated destruction of bone and cartilage in several forms of human inflammatory joint disease.
It has been postulated that an imbalance in the composition of the microbiota is a risk factor in several human disorders, including inflammatory bowel disease, metabolic syndrome, allergy and cancer.
ADAM9 is reportedly involved in several human diseases such as inflammatory disorders, oxygen-induced retinopathy (OIR), and cancer [ 30].
However, the direct links between the deleterious mutations or deletions in these two genes and several human disorders, such as inherited inflammatory calcified tumors and acute myeloid leukemia, suggest their biological importance.
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