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This experimental approach inspired multiple human cell therapies, spanning both allogeneic and autologous T cell transfers.
HIV is capable of infecting multiple human cell types, but for simplicity's sake, we will focus on HIV infection of CD4-positive immune cells, a.k.a.a
Gene targeting with adeno-associated virus (AAV) vectors has been demonstrated in multiple human cell types with maximal targeting frequencies without engineered nucleases.
The recently developed gene editing approach called clustered regularly interspaced short palindrome repeats-associated nuclease (CRISPR -Cas9, CRISPR -Cas9y knocanout most regions of the genome at the DNA level with fewer OTEs than RNAi, in multiprecisely cell types, thus overcoming the limitations of the other approaches.
Experimental excessive ROS stress can trigger cellular senescence in multiple human cell lines [13], [14].
In fact, an absence of PHD3 upregulation following hypoxia has been observed in multiple human cell lines from tumors of the breast, prostate and brain [10], [16].
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We developed DENdb, a centralized on-line repository of predicted enhancers derived from multiple human cell-lines.
NGAL, known as lipocalin 2, and initially described as an oncogene expressed by multiple human cells, including epithelial cells and neutrophils [ 4].
Here we report the computational detection of an interchromosomal RNA fusion between ZC3HAV1L and CHMP1A from RNA-seq data of normal human mammary epithelial cells, and experimental confirmation of the chimeric transcript in multiple human cells and tissues.
Using 467 in vitro assays across 9 technologies, including high-throughput cell-free assays and cell-based assays in multiple human primary cells and cell lines, they investigated a broad spectrum of chemical activities at the molecular and pathway levels.
We tested 309 mostly pesticide active chemicals in 467 assays across nine technologies, including high-throughput cell-free assays and cell-based assays, in multiple human primary cells and cell lines plus rat primary hepatocytes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com