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Our design is motivated by a B-cell Non-Hodgkin Lymphoma trial evaluating multiple dosing regimens within multiple disease subtypes.
Complex diseases like diabetes, stroke, many types of cancer, and chronic obstructive pulmonary disease (COPD) are likely heterogeneous syndromes composed of multiple disease subtypes that manifest a similar pathological or physiological outcome.
Biological annotation of the genes selected and the networks built to mark and separate different pathological states confirm the value of using geNetClassifier to analyse multiple disease subtypes based on genome-wide expression profiles.
Many clinical and biomedical studies look for the separation between multiple disease subtypes as distinct pathological states, but they are also very interested in finding the specific genes that are altered in each disease subtype.
B-cell non-Hodgkin lymphoma (B-NHL) is a clinically heterogeneous disease that is currently classified into multiple disease subtypes defined by discrete clinical, morphological, immunological and genetic features (Swerdlow et al, 2008).
Similar(55)
Aberrant mitochondrial morphology is linked to multiple disease manifestations caused by mutations in genes involved in fission and fusion, like Charcot-Marie-Tooth subtype 2A and dominant optic atrophy [18], [28].
Moreover, the integrated evaluation of multiple additional biomarkers (i.e. autoantibody specificities, cytokine levels, and bone-turnover products) enables the stratification of RA into disease subtypes and provides further insight into disease pathogenesis at the individual level.
The physiological manifestations of Parkinson disease are heterogeneous, as evidenced by disease subtypes.
We pool safety data across disease subtypes and use a single dose-toxicity model while sharing efficacy information between disease subtypes using a hierarchical dose-response model.
Associations for disease subtypes are uncertain.
And different disease subtypes also have different sizes.
Related(20)
various disease subtypes
many disease subtypes
multiple disease samples
multiple disease phenotypes
multiple disease portals
multiple disease mechanisms
multiple disease outcomes
multiple disease pathogeneses
multiple disease contexts
multiple disease models
multiple disease targets
multiple disease indications
multiple symptom subtypes
multiple integrin subtypes
multiple disease indicators
multiple disease risks
multiple disease states
multiple disease entities
multiple disease conditions
multiple disease genes
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