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Overall, we have identified several valuable new inhibitors of legumain that can be used to study legumain function in multiple disease models.
Such evidence, combined with our study, suggests that WSX1 plays a key role in downregulating the immune response in multiple disease models.
The authors also showed that treatment with Harmine inhibited inflammation in multiple disease models.
Genes involved in protein folding (e.g. heat shock proteins), protein degradation and autophagy were discovered across multiple disease models.
Previously, the PD-1 pathway has been described to limit the inflammatory response in multiple disease models 15.
However, studies performed in multiple disease models showed that exenatide did not evoke pancreatitis and in some instances attenuated the condition 12.
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Compounds representing each of the chemical classes of HDACi have been used successfully in prophy-lactic and therapeutic protocols in multiple animal disease models, including those for asthma, systemic endotoxic shock, colitis, lupus, multiple sclerosis and graft versus host disease [ 67, 68].
Our computational model was able to match liver regeneration profiles across multiple chronic disease models and across species.
Region-specific early alterations to the CLN6-colocalizing metal transporter, Zip7, in multiple CLN6 disease models indicate an important role of this metal transporter in CLN6 NCL.
Zip7 was thus the only transporter with altered expression in multiple CLN6 disease models [ 15], and the only ER-localized metal transporter to be altered.
Using the extracted study seroprevalence data, prevalence of HBeAg was modeled using Dismod III v3.0, a generic disease modeling system [ 22], which models multiple disease parameters, including incidence, prevalence, remission, and mortality, in order to ensure consistency among the parameters.
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multiple disease systems
multiple disease states
multiple disease phenotypes
multiple disease mechanisms
multiple disease portals
multiple disease loci
multiple disease outcomes
multiple disease pathogeneses
multiple disease factors
multiple regression models
multiple disease targets
multiple disease indications
multiple disease indicators
multiple disease risks
multiple imputation models
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