The rapid growth of minimally invasive, image-guided intervention has redefined the procedural management of multiple disease entities.
It remains unclear whether this reflects the coincidence of two or more disease entities (for example, AD independently in addition to DLB) or whether Aβ (and tau) pathology can be found independently in multiple disease entities.
NCDs also bring great complexity to global health, since they represent multiple disease entities, with various age and sex profiles and – among the oldest sectors of a population – are to some degree unavoidable.
However, confusion still exists as to how a single genetic aberration can be associated with multiple distinct disease entities.
Hence, the scientific community endeavored to either infuse or inject stem cells in multiple organ-specific disease entities with only limited clinical success in myocardial infarction (Jensen & Patterson, 2013; Lemmens & Steinberg, 2013; Wollert & Drexler, 2010).
When placed in this context, the need for a greater awareness from both the physician and patient of the importance of managing a patients' overall health status within the context of multiple disease states, rather than a single disease entity, is highlighted.
23 29 Also, peripheral and cerebrovascular disease may to some extent represent "disease staging" of underlying atherosclerosis that has progressed to multiple vascular systems, rather than representing separate disease entities.
inherited mutations in SCN5A, the gene encoding the pore-forming subunit of the cardiac type Na+ channel, cause a spectrum of disease entities, Na+ channelopathies, which include multiple arrhythmic syndromes.
Among the disease entities proposed by the 6 panel members subscribing to a multiple-disease view, only a few entities were similar across two or more physicians, the best agreement being found for the two entities described as "allergic wheeze associated with interval symptoms" and "exclusive viral wheeze occurring only during viral infections".
However, in large multiple sclerosis populations, the range of ages of onset is very broad to an extent matched by few disease entities.
Beyond its approval, rituximab is being used and/or evaluated for further disease entities like immune thrombocytopenia [ 5], autoimmune hemolytic disease [ 6], posttransplant lymphoproliferative disorders [ 7] and multiple sclerosis [ 8].
