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The interactions between PGRN and TNFR have been demonstrated by many laboratories in multiple disease contexts, indicating that the balance of TNF-α/PGRN is crucial to the development of these diseases.
The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target.
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β-Catenin plays important roles in multiple cellular and disease contexts but much remains to be learned about the regulation of β-catenin in the different cellular contexts, including pivotal ones in the human central nervous system.
Utility values were drawn from a secondary source because it was not feasible to obtain primary data for multiple disease states within the context of this study.
Together, these technologies will help us dissect both the spatial and temporal dynamics of ECM homeostasis, and promote our understanding of the underlying mechanisms that influence cell-ECM interactions in the context of multiple disease types.
When placed in this context, the need for a greater awareness from both the physician and patient of the importance of managing a patients' overall health status within the context of multiple disease states, rather than a single disease entity, is highlighted.
In the context of the current CML therapy, we anticipate multiple disease remissions and relapses over time, which means that r will be dependent mainly on the follow-up of the particular group of patients.
Besides the classic classification of identities into prerenal, renal and postrenal, AKI can also be regarded as a syndrome occurring in the context of multiple diseases.
Finally, the REVEAL study focused on single gene testing for AD risk, and findings may not generalize well to contexts where multiple genes and multiple diseases are addressed.
Although published studies have described methods for assessing relationships between disease diagnostic categories in a network context [ 6, 29], we instead focused on multiple disease-related phenotypes within one complex disease.
"He had multiple diseases from his obesity".
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Justyna Jupowicz-Kozak
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