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Over the following years, multiple disease genes associated with cystic kidneys were identified, and almost all of the corresponding gene products were found to localize to primary cilia [1,6].
The diagnostic screening of multiple disease genes results in the identification of unprecedented numbers of sequence variants.
The co-segregated genomic loci can also be very large, and multiple disease genes may be present under the QTL.
These data demonstrate that the expanded trinucleotide repeat within ATN-1 mRNA is a potential target for compounds designed to achieve allele-selective inhibition of ATN-1 protein, and one agent may allow the targeting of multiple disease genes.
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In addition to containing manually curated information on disorders of interest to neurodevelopmental researcher, Neurocarta aggregates data from multiple disease gene resources so that the neurodevelopmental annotations can be examined in the context of other disease annotations, providing a better understanding of how generic the function of the gene might be.
The evidence for the presence of multiple disease resistance genes in a maize association population [ 43] revealed that quantitative BSR can be conferred by a single gene.
The strong activation of the multiple disease defense genes in these plants was associated with a clearly enhanced HR reaction to invading bacteria, as compared to wild type plants.
These findings suggest that mutations in multiple glomerular disease genes explain some of the phenotypic variability in nephropathies.
In the above two PPI network-based approaches, those unknown genes directly interact with one or multiple confirmed disease genes are likely to be predicted as candidate disease genes.
The potential clinical applications of RNAi represent a strategy with unsurpassed selectivity, with the ability to target multiple disease-related genes, independent of their perceived drugability.
The temporal expression of multiple disease-associated genes with potential pathophysiological roles in the reactivation model of SCW-induced arthritis in Lewis (LEW/N) rat has not previously been fully addressed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com