Verapamil (MW 454.6) is a Ca++-channel blocker with multiple disease indications (implying considerable promiscuity, consistent with a log P value of 3.79 http://www.drugbank.ca/drugs/DB00661).ca/drugs/DB00661
Rapamycin, a drug currently approved for multiple disease indications, extends lifespan in yeast (Kaeberlein et al., 2005b; Powers et al., 2006), flies (Kapahi & Zid, 2004; Bjedov et al., 2010), worms (Vellai et al., 2003), and mice (Chen et al., 2009; Harrison et al., 2009).
Inflammation acting as a driver of pathology has previously been thought to be primarily restricted to infectious diseases and autoimmune disorders; however, it has become more apparent that inflammation plays a larger role in multiple different disease indications, such as obesity, coronary artery disease and cancer [ 1, 2].
Moreover, there is emerging in vivo data to support the role of CB2R as a therapeutic target in other disease indications including osteoporosis, multiple sclerosis or in other diseases with an inflammatory component such as allergic contact dermatitis, colitis and atherosclerosis.
In support of this hypothesis, high CD319 expression has been observed on plasma cells or B cells from several disease indications including systemic lupus erythematosus [ 17], and the transformed cells in multiple myeloma [ 16] indicating the potential for CD319 as a therapeutic target for plasmablast and/or plasma cell-driven diseases.
Because several targets are important for multiple disease areas (e.g., vascular endothelial growth factor [VEGF] as a significant target in both oncology and ophthalmology indications), there are more uses listed than antibodies.
Thus far, antibody mixtures are being used mostly for oncology and infectious disease indications.
Leukemia is the most common cancer subtype and accounts for 57.4% (n = 120) of disease indications.
There are many versions of adaptive enrichment proposed across many disease indications.
To demonstrate the applicability of the biomarker retrieval terminology in other disease indications independently of the oncology-focused training corpus, the performance of retrieval for biomarker-related abstracts from Medline was tested in the field of Alzheimer's disease and multiple sclerosis.
In addition to the clinically valuable information embedded in the imaging findings related to the chest CT indication, incidental findings that are unsuspected or unrelated to the indication contain prognostically valuable information about multiple diseases [ 3– 5].
