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Induction of NSCLC in mouse lung has also been examined by conditional expression of mutant K-Ras [4].
The cellular tropism of SARS-CoV in mouse lung has also been investigated by Ling et al., 2006 [8].
Studies have demonstrated that SERT is expressed almost exclusively on pulmonary arteries in rat lung (Morecroft et al. 2005), but the precise localization of SERT in mouse lung has not been determined.
A correlation of cell proliferation and tumor development in mouse lung has shown that target cell hyperplasia is not a necessary prerequisite for enhanced tumor development.
Single-dose AdCre administration into the mouse lung has been reported to cause inflammatory lymphocyte infiltrations that are persistent for at least 4 weeks in wild-type mice and for up to 24 weeks in KRASG12V mice (Mainardi et al, 2014).
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However, one mouse lung had three small metastatic nodules (indicated by red arrows in Figure 5), which differed slightly from the bioluminescence imaging result in Figure 4A.
Changes in S. aureus gene expression during early adaptation to the mouse lung have been described [ 19], and Date et al. recently reported global S. aureus gene expression in human abscesses and infected murine kidneys [ 20].
The Scgb3a2 transgenic mouse lungs had a much more drastic reduction in Il6 and Tnfa mRNAs as compared to wild-type.
Alterations in human and mouse lungs have been described for fatal virus infections with pandemic virus strains (subtypes H1N1, H2N2, and H3N2 strains of 1918, 1957, and 1968, respectively) or subtype H5N1 strains.
These results suggested that the Scgb3a2-transgenic mouse lungs had altered cellular metabolism and homeostasis with higher expression levels of genes associated with inflammation, and cellular signaling and movement, which may have played a role in the more susceptible phenotype of Scgb3a2-transgenic mouse lungs to BLM-induced fibrosis at 3 weeks post-BLM treatment.
For example, the mouse gene H2-Ab1 ranked 42 in PC2 in the developing mouse lung dataset has the 42-nd highest loading coefficient magnitude in PC2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com