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Each dysferlin-deficient mouse strain has been characterised to varying degrees using a variety of histological and functional assays, occasionally producing results inconsistent with other strains.
Each mouse strain has been engineered with a single genetic mutation identical to one of the dozens already discovered in people with autism, and the mice exhibit behaviors that resemble those on the human autism spectrum, primarily impaired social interactions and repetitive behavior.
This mouse strain has a deletion of the TLR4 locus, causing the mouse strain to be nonresponsive to stimulation by LPS from Escherichia coli while responding normally to other bacterial substrates, such as lipoteichoic acid (LTA) from Staphylococcus aureus, which signal TLR4 independently.
The Rb1ΔL mouse strain has been described previously [28].
The generation of the pR5 mouse strain has been previously described [20], [35].
The used mouse strain has considerable and variable impacts on different aspects of the asthma phenotype.
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An α1B-receptor deficient mouse strain had been generated (Cavalli et al, 1997) and had been reported to show 'normal' activity in a novel chamber or open field (Spreng et al, 2001); however, a second group did report a significant reduction in the open field activity with this strain (Knauber and Muller, 2000).
At 8 months post infection, the level of neutrophil infiltration in this mouse strain had dropped back to basal levels.
MEFs from the homozygous Actb-MBS mouse strain have been previously described (Lionnet et al., 2011).
Several surveys of body weight and composition on a mouse strain have been conducted [ 8– 14].
Previous studies of cultured cells derived from this transgenic mouse strain have focused on the properties of fibroblasts [ 12].
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