Studies in rat lung have shown that arsenite enhances the binding of AP-1 to DNA and induces stress protein expression, including heat-shock proteins HSP32 and HSP72 (Wijeweera et al. 2001).
A number of miRNA profiling studies evaluating mouse and rat lung development have recently emerged and demonstrated the dynamic regulation of miRNAs during lung organogenesis.
Both human and rat lung tissue have the capacity to form 9-hydroxy-2-nitrofluorene (9-OH-2NF) that is mutagenic.
Radionuclide injury to the lung has been studied in rats, hamsters, dogs, mice and baboons.
Studies have demonstrated that SERT is expressed almost exclusively on pulmonary arteries in rat lung (Morecroft et al. 2005), but the precise localization of SERT in mouse lung has not been determined.
In the present study, our aim was to find out if tezosentan reverses the rise in microvascular filtration coefficient (Kfc) in rat lungs that have been isolated and perfused 12 h after cecum ligation and puncture (CLP) or infusion of ET-1.
In this study, a novel rat lung slice methodology has been developed and applied to study drug uptake in lung tissue, and the mechanisms by which this occurs.
The effects of different degrees of lung distention were studied in rats whose lungs had been injured by α-naphthylthiourea (ANTU) [38].
The effects of different degrees of lung distention were studied in rats whose lungs had been injured by α-naphthylthiourea (ANTU) [ 38].
The profibrotic role of E2 has been confirmed in the bleomycin-induced rat lung fibrosis model where female animals had a more profound fibrotic response compared with males, which was attenuated following ovariectomy and accentuated with HRT [ 51].
