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The adult mouse liver has served as an experimental paradigm for tissue regeneration for decades.
As such, variable levels of human chimerism is often achieved[8], [10], [11] and complete humanization of mouse liver has never been achieved.
The main difference is that the mouse liver has a gall bladder.
Recently, the crystal structure of aldehyde oxidase of mouse liver has been reported.
A lesion sequence for carcinogenesis in male B6C3F(1) mouse liver has been proposed that will enable development of a biologically based mathematical model for DCA.
These findings agreed well with the facts that the mouse liver has a critical role in blood supply at the early stages TS18-199) and begins to function in metabolism starting from TS21 [ 3].
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Inheritance of the vTK minigene by SCID/uPA mice did not appear to impact inherent ability of endogenous MH to develop into RN since by 3 months old, vTK+SCID/uPA mouse liver had architectural features that typically mark the hepatocellular disease seen with age-matched SCID/uPA mice[9], [26].
Reactive electrophilic metabolites of ethyl carbamate and of safrole and estragole and their nucleic acid adducts formed during initiation in mouse liver have been characterized.
Overall, our results show that genes that were highly stable in mouse liver had orthologs in other species that were also highly stable.
Although mouse liver had proved to be a poor choice for purification of Nat enzymes (Watson et al., 1990), mouse Nats were most suitable for recombinant protein studies and excellent for investigation of Nat in development.
Two major SREBP isoforms expressed in mouse liver have partially overlapping but differential gene targets: SREBP-1c mainly regulates genes involved in fatty acid synthesis, whereas SREBP-2 regulates genes involved in cholesterol synthesis and uptake, including Ldlr and Pcsk9[ 23].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com