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AEPO-liposome treatment significantly reduced TTC-defined cerebral legion following cerebral I/R injury, and ameliorated motor function compared with vehicle and AEPO treatment.
While IVIT atropine was shown to improve movement in intact rats Cogentin treated rats showed impairment of motor function compared to control rats or to rats treated with any other cholinergic drug.
As a result, muscles in the POMT mutant have duplicated basal membranes and decreased motor function compared to those of wild-type flies.
High susceptibility to dietary obesity was associated with increased osteoarthritic changes in the knee and impaired musculoskeletal force generation and motor function compared with controls.
Animals expressing C-terminal-truncated FUS513 (69.7 ± 8.9/min) or FUS501 (54.6 ± 8.7/min) also had significantly impaired motor function compared with WT-FUS (P< 0.001).
Appropriate exercise, when combined with olfactory ensheathing cell transplantation significantly improved motor function, compared to cell transplantation alone in rat (Kubasak et al., 2008).
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MAOB-I treatment showed significant improvement in sensory and motor functions compared to saline treatment (p < 0.05 0.001) in injured nerves.
A potential explanation for this result might be that at 3 months after surgery, despite improved neurological function and somewhat improved sensory and motor functions compared with the preoperative conditions, factors such as postoperative wound pain and wound-related restrictions on activities prevented direct reflection of improved neurological function in the patients [ 26- 29].
Recently, a small non randomized trial of children with neurological impairments aged 1 – 14 years showed that those who received 6 months of additional nasogastric tube feeds, had improved growth and gross motor functioning compared with a group who did not receive supplements [ 30].
First, 10 weeks of sodium nitrite supplementation in healthy, highly functioning MA/O adults increased plasma nitrite levels and improved several measurements of motor and cognitive function compared with placebo control.
Moreover, the extension-flexion ratio, a parameter to judge voluntary movements without body weight support, revealed no significant differences among the experimental groups of mice, although L1 overexpressing SENAs showed a tendency towards improved motor function when compared to wild-type SENAs and sham-injected PBS three and six weeks after injury (Fig. 1D, H).
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