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Irrespective of gender, Danish preschool children perform well in aiming and catching, but, similar to other countries, poorer in motor coordination compared to norm-referenced data.
Interestingly, depending on the difficulty of the task, assessments of Ts65Dn mice in the rota rod test revealed a range of phenotypes, from moderate-to-severe deficits to improvements in balance and motor coordination compared with their control littermates (21, 51, 54– 54).
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The rump-height index and the extension flexion ratio, which require more complex motor control and coordination compared with plantar stepping, were not improved by L1 overexpressing SENAs when compared to wild-type SENAs although L1 overexpressing SENAs but not wild-type SENAs showed an enhanced rump-height index when compared to sham-inject mice six weeks after transplantation.
We observed that surviving mutant mice were severely impaired in their motor coordination performance compared with their WT littermates and that the difference was more evident at 2 months of age compared with 1 month (two-way ANOVA repeated measurements, Bonferroni's post-hoc comparison test, 1 month P>0.05; 2 months P≤0.05, WT versus MUT P8 P20 PT).
The results obtained indicated that mutant mice treated with AAV had no obvious motor coordination impairment compared with wild-type control littermates at any time point (Fig. 7 B).
Approximately 50% of children with ADHD [ 17, 18] and 60-80% of children with ASD have poor motor coordination [ 19, 20] compared with 6% in the general population [ 21].
Young RasGrf1 −/− mice displayed superior motor coordination in the tightrope test as compared to WT controls.
Ifnb –/– mice were significantly impaired in motor coordination and learning from 3 months compared to age-, sex-, and weight-matched wild-type (WT) Ifnb +/+ littermates and in latency-to-fall time in a wire-suspension test.
In our lifelong study, aging decreased equilibrium, motor coordination, and muscular vigor in Old compared to Young controls, and all these detrimental changes were totally (equilibrium) or partially prevented by atenolol.
Motor coordination and muscular vigor (Fig. 6B,C) were strongly decreased in Old compared to Young controls.
From the age of 18 months, p23-ST1 mice displayed poor performance on the rotarod running test compared to control mice (Fig. 4) suggesting a decline in motor coordination.
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