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As shown in Figure 2A caffeine pre-treated adult WT females displayed increased (121.7±2.1) spontaneous motor activity compared to the WT untreated females (113.3±1.2) (p = 0.0008, t = 3.68, df = 35 Student's t test).
Trend analyses for Hyperactivity factor scores revealed a strong linear trend (F 2,109) = 19.09, p < .01) without a quadratic trend (F 2,109) = 0.79, p = .38) indicating that, as predicted, the non-affected sibling group showed an intermediate level of motor activity compared to the more hyperactive ADHD group and the less hyperactive healthy control group.
At 20 months, a motor defect is clearly observed and the adult homozygous T70I sod1 zebrafish spend a greater proportion of time at the bottom of the tank and in the 'resting' phase of motor activity, compared with their WT clutch mates.
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As previously reported [21], GSK+/− mice were healthy, fertile, had normal circadian rhythms and life span, but had unimpaired motor and locomotor activity compared to their WT littermates (see Supporting information Fig. S2).
PSI-treated transgenic mice showed significantly reduced open field motor activity as compared to PSI-treated wild-type age-matched control mice (Fig. 1a, b).
Further, their adult MD lesion rats exhibited no changes in motor activity when compared to controls at 7 weeks post-lesion.
The quantitative data from multiple experiments demonstrate that the Myo Va motor domain (41-505) significantlyicantly more binding activity compared to the 800-881 construct (Fig. 2D, p<0.015).
Specifically, the β-MHC isoform is a slow motor protein that is more economical in its ATPase activity compared to the α-MHC isoform [33].
Moreover, little is known about the effect of graded activity compared with supervised exercise program (strengthening, stretching and motor control) in patients with non-specific cLBP.
We found that GFP-hSOD1G85R overexpression induced SOD1 inclusions and reduced proteasome activity compared with the overexpression of GFP alone in NSC34 motor neuronal cells.
General reaching-related activity compared with fixation mainly clustered in the left hemisphere (Fig. 2 a ), spanning from motor cortex over somatosensory cortex to the PPC.
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