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Primary outcomes in this study were gross motor function (measured with the Gross Motor Function Measure and functional muscle strength tests) and walking ability (measured with the 10-meter, the 1-minute and the timed stair test).
To establish test-retest reliability of Intrinsic Foot Muscle (IFM) motor function measured using ultrasound imaging (USI).
We show that our heat kernel features are able to successfully predict motor function measured at two years of age (sensitivity, specificity, F-score, accuracy = 75.0, 82.5, 78.6, and 82.3%, respectively).
We consider a difference on gross motor and fine motor function measured on PDMS-2 between the intervention and the control group of 0.5 SD as clinically significant.
Recent studies have shown that it is positively correlated with motor function measured by the GMFCS [ 13- 15, 25, 32, 34, 37].
Conflicting evidence was found on the effectiveness of strength training on gross motor function measured by GMFM compared to no training [ 44, 46, 48].
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The scores in the tests were partially correlated with each other, and with clinical measures such as vital capacity, Motor Function Measure, functional hand scale and Brooke score.
Altogether, eight repeated measures with three-dimensional gait analysis and five clinical measurements using the gross motor function measure (GMFM) were performed.
Furthermore, a caregiver-reported COA would be complementary to other clinician-reported, performance-based outcome measures that may be used in clinical trials, such as the functional mobility scale (FMS), gross motor function measure (GMFM-88) and gross motor function classification in MLD (GMFC-MLD) [13, 14, 15].
Existing measures, such as Motor Function Measure, Tapping, and the Brooke Upper Extremity Functional Rating Scale were also performed.
Since therapeutic approaches to MLD are being explored, we evaluated a wide range of potential markers of disease severity including biochemical and molecular analyses (ASA activity, genotype, ASA mRNA levels, and residual ASA CRIM), measurements of motor function (GMFM-88, gross motor function measure-88), brain MRI and MR spectroscopy, neurophysiological assessments and sural nerve biopsy.
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motor speed measured
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motor threshold measured
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