Among HAND1-associated genes, we identified DHRS9 as the most induced gene (210-fold induction; Figure 7b).
Interestingly, superarray data identified CDH1 as being the most induced gene by panobinostat treatment specifically in MDA-MB-231 cells, as these cells are characterized as mesenchymal, thus lacking significant CDH1 expression.
In the carotenoid biosynthesis pathway between A1 and A9, as the most induced gene, -abscisic acid 8′-hydroxylase changed by 5.64 fold, while NCED, as the most down-regulated gene, changed by −4.15 fold.
GmNAC085, whose amino acid sequence was 39%; identical to that of well-known SNAC1/ONAC2, was the most induced gene upon dehydration, showing 390-fold and 20-fold induction in shoots and roots, respectively.
Interestingly, among the UGT-encoding genes, the most induced gene (Bradi5g03300) exhibiting a log2 fold change of more than 6.5 between the two infection conditions encodes a UGT already shown to be able to detoxify DON into DON-glucose [ 40].
This included cyclin G2 (CCNG2), the most induced gene in our array set and is FOXO regulated, Cbp/p300-interacting transactivator (CITED2), phosphatase and tensin homologue (PTEN), breast cancer 1, early onset (BRCA1), all three significantly transcribed after exposure to ETP-45658.
