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In the first part, the most important gene candidates such as COMT or SLC6A4 gene are presented.
The hypocretin receptor 2 gene could be the single most important gene in human narcolepsy, says Michael Aldrich, a neurologist and director of the University of Michigan's Sleep Disorders Center.
Probably the most important gene in this context is the pro-opiomelanocortin (POMC) gene, which codes for the production of several molecules with pleiotropic effects [see 10].
TBX1 is the most important gene for 22q11DS.
First and most important, gene drives require many generations to spread through populations.
For example, SCD was identified as the most important gene in regulating TG accumulation.
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ZmCCT is one of the most important genes affecting photoperiod response.
By simulating this filtration process, SGA focuses the search around the most important genes thereby improving GA's efficiency.
The ZmCCT, one of the most important genes affecting photoperiod response, delays flowering under long-day conditions in maize (Zea mays).
Genes ftsZ and mreB encoding proteins of bacterial fission ring and skeletons, respectively, are essential for cell growth, they both are the most important genes keeping the bacterial shapes including the cell length and width, respectively.
For example, 10 years ago it took over 12 months and cost over £1,000 to analyse BRCA1 and BRCA2 (the two most important genes for hereditary breast and ovarian cancer), but today we can do this as an NHS service for less than half the cost in a matter of weeks.
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Justyna Jupowicz-Kozak
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