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Nucleophosmin-1 (NPmutationsions represent the most frequent gene alteration in acute myeloid leukemia (AML).
As the number of baseline significant networks varies between the HLA risk groups, all genes appearing more than half as many times in baseline significant modules as the most frequent gene were used to seed a consensus HLA risk group-specific network associated with T1D.
The inability to predict synergy from genetic lesions is probably hampered by the necessity to restrict the analysis to recurring and highly focal copy number lesions as identified by GISTIC and the focus on the most frequent gene mutations in NSCLC.
The most frequent gene mutation was BRAF.
We found deletions to be the most frequent gene copy number variation in relation to RRM1.
The most frequent gene aberration in lipomas is HMGA2/LPP [ 8].
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Table 2 summarises the most frequent genes within each group.
Top 22 most frequent genes occurring in 12 or more signatures are listed in Table S3 (Additional File 1).
Table 2 lists these sub-networks with detailed information on both biological themes and the most frequent genes.
The most frequent genes were KIAA0241 protein (KIAA0241) for ER-positive tumors, and zinc finger protein multitype 2 (Zfor2) for ER-negative tumors.
The two most frequent genes are endoglin (ENG) on chromosome 9 and of activin-receptor-like-kinase 1 on chromosome 12 [ 2].
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