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This information should be useful for selecting the most informative gene to resolve any relationships, especially those that are difficult to resolve, as well as minimizing both cost and confounding information during project design.
In this way, the least informative gene that is indicated by very low
As a consequence, CAD was our most informative gene fragment.
The simplest approach may be to search for the single most informative gene that is differentially expressed between responders and nonresponders.
It was observed that the 250th most informative gene had a p-value between classes less than 0.001 thus giving an idea about the level of information that the genes imparted to the system.
In addition, the contribution of Isolation by Distance (IBD) was estimated using the most informative gene data set (COI) in GenAlEx 6.1 [ 51] with 999 permutations using the Mantel test in GenAlEx 6.1, initially for the group as a whole and subsequently for each clade individually, excluding the Zambian and Malawian clades that originated from one site each, preventing analysis.
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More specifically, individual genes are used as the classification features while the PPI network information is used in feature selection to identify the most informative genes.
It will also be useful to develop gene set similarity measures weighted to consider the most informative genes in the gene set (such as the most differentially expressed).
As the least and most informative genes were calculated by FCDF, the least informative genes are replaced by the most informative ones, and hyper-box enclosure method is used at each iteration.
The most informative genes for separating bladder and renal UCs were selected in two steps.
Similarly to prostate cancer, we selected the most informative genes separating the groups for each study.
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