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The molecular mechanisms that direct intestinal epithelial cell morphogenesis and terminal differentiation are poorly understood.
Conclusions: Elf3 is an important regulator of morphogenesis and terminal differentiation of epithelial cell lineages in the small intestine.
Seventy percent of the Elf3-deficent progeny were born and displayed severe alterations of tissue architecture in the small intestine, manifested by poor villus formation and abnormal morphogenesis and terminal differentiation of absorptive enterocytes and mucus-secreting goblet cells.
Together, these data demonstrate that there is no luminal cell-autonomous role for Id1 in mammary epithelial cell fate determination, ductal morphogenesis and terminal differentiation.
In fetal mice, lung epithelial cells are initially specified by Nkx2.1 expression around embryonic day (E) 9.5, followed by lung bud growth, airway branching morphogenesis, and terminal saccular formation [ 3].
Our results suggest that the combinatorial control of gene expression via cis-acting enhancer sequences and core-promoter types, determine the complex changes in gene expression that drive morphogenesis and terminal differentiation of the Drosophila wing epithelium.
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We observed a dose-dependent inhibition of branching morphogenesis and enlarged terminal buds (Fig. 3I and L) as reported previously (9).
Together these observations indicate that miRNAs are dynamically involved in tooth development by fine-tuning tooth morphogenesis and patterning, as well as terminal cell differentiation and tissue homeostasis.
Moreover, loss of one allele of p190B transiently delays ductal morphogenesis and results in decreased proliferation within the terminal end buds, which drive ductal penetration into the fat pad [ 8].
This unique system allows the monitoring of implanted mammary cells during their developmental progression leading to the formation of a fully functional mammary gland, including ductal elongation, terminal end bud formation, branching morphogenesis, and alveolar development.
It services include container, bulk, and terminal.
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