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This gene is a regulator of mammary epithelial cells apoptosis during both morphogenesis and involution of the mammary gland.
Further, the role of the metalloproteinase axis in mediating inflammation and immunity during morphogenesis and involution currently remains unexplored.
In this study, we have explored a role for PKC δ in the apoptosis of primary MECs during branching morphogenesis and involution.
It is apparent that metalloproteinases participate during morphogenesis and involution, but the current knowledge on how they may influence immune cells during these critical windows is completely untested.
In the mouse mammary gland, MMP mRNA and activity are evident during branching morphogenesis and involution [ 12, 68- 70]; and in transgenic mice, overexpression of active MMP 3, MMP 7 (matrilysin), and MMP 14 (MT1-MMP; membrane type-1-MMP) led to ductal hyperplasia and in the case of MMP 3 and MMP 14 also to tumorigenesis [ 69- 73].
Similar(54)
HGF/SF and TGF-βs appear to have important roles in branching morphogenesis, lobuloalveolar development, and involution in mice.
In the mammary gland in vivo, apoptosis is critical for ductal morphogenesis during puberty and involution following lactation.
Once established, the mammary gland undergoes rounds of highly orchestrated proliferation and morphogenesis during pregnancy and involution, yet without losing the fundamental patterning of the gland.
In the mammary gland, where a restricted expression pattern was observed, it would be interesting to explore the dynamic nature of gene expression of this small number of genes in ductal branching morphogenesis, alveolar bud formation, lactation and involution because this might reveal novel insights into mammary gland development in the adult.
The vitamin D3 receptor (VDR) serves as a negative growth regulator during mammary gland development via suppression of branching morphogenesis during puberty and modulation of differentiation and apoptosis during pregnancy, lactation and involution.
Mr. Fisher makes too much of Henry's famous late style as a symptom of concealment and involution.
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morphogenesis and maturation
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morphogenesis and reproduction
morphogenesis and pattern
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morphogenesis and homeostasis
morphogenesis and skeletal
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morphogenesis and cycle
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morphogenesis and disease
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