Sentence examples for morphogenesis and tumorigenesis from inspiring English sources

Our results thus indicate that in addition to its anti-apoptotic function, Bcl-2 may be also involved in EMT during normal morphogenesis and tumorigenesis.

We conclude by emphasising the urgent need to identify the molecular targets of the progesterone receptor, and to determine whether these targets are modulated differently by the progesterone receptor isoforms (A and B) during mammary morphogenesis and tumorigenesis.

In recent years, increasing studies indicate that miRNAs have crucial functions in specific cellular processes such as differentiation, morphogenesis, and tumorigenesis and they are also considered as oncogenes and tumor suppressors [ 9– 12].

Together, these functional analyses in different representative organisms along the phylogenetic tree indicate that the ancestral function of Brachyury was the promotion of cell movement and adhesion, which are fundamental for both morphogenesis and tumorigenesis.

Our findings, together with the striking similarities in mammary development and tumor phenotypes between Becn1 +/− and MMTV- Tnfrsf11a (or MMTV- Tnfsf11) mice, suggest that the TNFRSF11A pathway may mediate the impact of monoallelic Becn1 loss on mammary cell hierarchy, morphogenesis and tumorigenesis.

In addition, several presentations addressed signaling molecules involved in branching morphogenesis and mammary tumorigenesis.

TGF β mediated induction of EMT processes is associated with specific stages of morphogenesis and during tumorigenesis by activating downstream signaling pathways in both Smad-dependent and Smad-independent mechanisms.

Proliferation is controlled, morphogenesis is restored and tumorigenesis is dramatically reduced when this integrin switching is reversed, despite the fact that genetic abnormalities acquired by tumor cells during progression persist [ 27, 29].

We propose that in vitamin-A replete conditions, RARα guards normal morphogenesis and influences wnt-induced tumorigenesis at least in part by maintaining a proper hierarchy of the mammary epithelial compartments.

In mammary gland development and tumorigenesis fibronectin is involved in motility and branching morphogenesis [ 6].

Although Wnt signaling has been shown to be important for embryonic morphogenesis and cancer pathogenesis of several tissues, its role in prostatic development and tumorigenesis is not well understood.