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Notably, morphogenesis and branching of respiratory epithelium depends on the timely expression and activity of transcription factors.
For example, the translational repressor Nanos (Nos) regulates dendrite morphogenesis and branching complexity of Drosophila class IV da neurons.
Ductal morphogenesis and branching of the resultant tubules can be induced by HGF/SF in primary and certain established mammary epithelial cells cultured in collagen gels or matrigel [ 23, 28, 29].
These studies together with our data demonstrating that Cdc42 overexpression disrupts MEC acinus morphology in three-dimensional cultures and TEB architecture in vivo, suggest that precise regulation of Cdc42 activity is important for proper MEC morphogenesis and branching.
Mammary gland morphogenesis and branching involve the regulatory function of several signaling pathways, including signaling by Wnt family members [ 7], transforming growth factor-β (TGF-β) [ 8], insulin-like growth factor-I (IGF-I) [ 9], and epidermal growth factor (EGF) and others [ 10].
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These results indicate that Celsr1 and Vangl2 are required for normal lung branching morphogenesis and disrupted branching in mutant lungs is not a consequence of space restriction.
PEA3 proteins play particular roles in branching morphogenesis and limb development [ 20].
MMPs, particularly stromolysin, are also involved in morphogenesis and over branching of the mammary gland [55].
Spry2 inhibits branching morphogenesis and neurite outgrowth in cardiocytes.
The miR-17/92 miR-17/92s involved also in normal lung morphogenesis, epithelial proliferation and branclusterhrough the targetisg of sinvolvedalsoucer and actinator of tranormaltion 3 (STAT3) and mitogen-activated protein kinase 14 (MAPK14).
These results support a model in which ectopic Msi expression leads to expansion of epithelial-luminal cells in the mammary gland, effectively blocking EMT processes required for normal branching morphogenesis, and resulting in the defective ductal branching pattern described above.
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morphogenesis and maturation
morphogenesis and terminal
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morphogenesis and tissue
morphogenesis and capillary
morphogenesis and copper
morphogenesis and function
morphogenesis and synaptogenesis
morphogenesis and reproduction
morphogenesis and pattern
morphogenesis and maintenance
morphogenesis and homeostasis
morphogenesis and tubulogenesis
morphogenesis and skeletal
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morphogenesis and cycle
morphogenesis and pathogenesis
morphogenesis and blood
morphogenesis and disease
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