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Cell proliferation is crucial for ureteric branching morphogenesis and nephrogenesis.
Specification of ureteric bud tip cells distinct from ureteric stalk cells is essential for ureteric branching morphogenesis and nephrogenesis.
These changes result in disruption of ureteric branching morphogenesis and nephrogenesis resulting in renal hypoplasia, likely due to impaired tip function.
Collectively, our data indicate that the TGFβ2/betaglycan signalling pathway has dosage-dependent actions within the fetal kidney, and that this pathway must be tightly controlled for normal branching morphogenesis and nephrogenesis to occur.
These findings indicate that a complete loss of betaglycan results in uncoupling of the reciprocal inductive signalling pathways that operate between the metanephric mesenchyme and ureteric epithelium to drive the progression of branching morphogenesis and nephrogenesis.
Furthermore, the opposing phenotypes in both Tgfb2 and betaglycan, null and heterozygote kidneys indicate that the TGFβ2/betaglycan signalling pathway has dose-dependent actions and that activity of this pathway must be tightly controlled for normal branching morphogenesis and nephrogenesis to occur.
Similar(54)
We evaluated the role of BMP-7, a protein required for renal injury repair and nephrogenesis, in disease progression in patients with obstructive uropathy.
At early stages, the expression of Six2 was normal and nephrogenesis initiated in contrast to Grem1-deficient kidneys.
In fact: 1) the principal functional category involved in the EMT process concerns morphogenesis and development; 2) the most up-regulated genes belong to this category; and, finally, 3) some intracellular pathways are involved, whose engagement during kidney development and nephrogenesis is well known.
In fact: 1) the principal biological categories involved in the process concern morphogenesis and development; 2) the most up-regulated genes belong to these categories; and, finally, 3) some intracellular pathways are involved, whose engagement during kidney development and nephrogenesis is well known.
Retinoic acid has been suggested for treatment of WT, which indicates the necessity to carefully study CRABP2 and retinoic acid in the context of WT and nephrogenesis.
Related(20)
morphogenesis and maturation
morphogenesis and tubulogenesis
morphogenesis and homeostasis
morphogenesis and disk
morphogenesis and terminal
morphogenesis and differentiation
morphogenesis and skeletal
morphogenesis and positioning
morphogenesis and pathogenicity
morphogenesis and assembly
morphogenesis and structure
morphogenesis and repair
morphogenesis and pathogenesis
morphogenesis and blood
morphogenesis and patterning
morphogenesis and tissue
morphogenesis and cell
morphogenesis and copper
morphogenesis and reproduction
morphogenesis and maintenance
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