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Pluripotent stem cell aggregates offer an attractive approach to emulate embryonic morphogenesis and skeletal development.
Surprisingly, mice lacking COMP have only minor skeletal anomalies, suggesting that absence of COMP is not detrimental to morphogenesis and skeletal development [16].
In addition, sdc-3 is involved in limb morphogenesis and skeletal development and regeneration [ 41, 42].
For H3K27me3, BTSCs gained this mark for receptors, especially G-protein coupled receptors, and lost this mark in the categories of embryonic limb morphogenesis and skeletal development.
We collected C. calyptratus embryos at various time points to study gene expression, morphogenesis, and skeletal and histological development of autopodial elements.
For M vs C females, genes involved in the processes cell proliferation, transcription regulation, tissue morphogenesis, gland morphogenesis and skeletal system development were upregulated while purine metabolism, pyrimidine metabolism, mRNA processing, M phase cell division and condensed chromosome were downregulated.
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As anticipated, those scoring highest are regarded as bilaterian-specific, related to nervous system development, embryonic organ morphogenesis, and embryonic skeletal system (fig. 5 B and supplementary table S2, Supplementary Material online).
Cartilage formation and skeletal morphogenesis depend on timely and abundant deposition of ECM proteins (DeLise et al., 2000).
Thus, DLX5, p63, Pin1 and FGF8 participate to the same time- and location-restricted regulatory loop essential for AER stratification, hence for normal patterning and skeletal morphogenesis of the limb buds.
WT embryos were injected with 100 pg of capped human EDARADD A or B mRNA or zebrafish edaradd mRNA at one-cell stage and skeletal morphogenesis was analyzed through alcian blue and alizarin red staining at 5.5 dpf.
It included genes encoding extracellular matrix constituents or organizers (Itga6, Col1a1 and Col1a2), but also transcription factors (Bapx1, Pcgf2, Sox10 and Tbx1) involved in skin and skeletal system morphogenesis or ondontogenesis.
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morphogenesis and bone
morphogenesis and maturation
morphogenesis and homeostasis
morphogenesis and tubulogenesis
morphogenesis and differentiation
morphogenesis and terminal
morphogenesis and nephrogenesis
morphogenesis and plasticity
morphogenesis and blood
morphogenesis and cycle
morphogenesis and pathogenesis
morphogenesis and tissue
morphogenesis and disease
morphogenesis and capillary
morphogenesis and copper
morphogenesis and function
morphogenesis and synaptogenesis
morphogenesis and reproduction
morphogenesis and maintenance
morphogenesis and pattern
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