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In particular, significantly more cell cycle and transcription genes were prognostic markers for ER+ tumors (Fisher's exact test, p = 0.0047), while prognostic markers of ER− tumors were significantly more likely to have functions related to angiogenesis and metastasis (Fisher's exact test, p = 0.023).

From day 7, more cell cycle regulators and p53 signalling genes were detected.

From day 7, more cell cycle regulators, p53 signalling genes, immune system related, MAPK and ERBB pathway genes were detected.

These included, "p53 signalling" and "Cell cycle regulation by B cell translocation (BTG)" (see Figure 4 for more cell cycle pathways).

The CTLA-4-expressing cells did not divide at all, whereas all CTLA-4 cells went through at least one more cell cycle.

Based on our current data, this may reflect the fact that more cell cycle regulated proteins have peak abundance in S, G2, and M phase than in G1 phase.

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This number will clearly increase as the tumor undergoes more cell cycles Fig. 3(a).

The micromeres themselves continue to follow the rule of alternating division chirality for one or more cell cycles.

At the tissue level, the probability of emergence of a malignant cell will increase with age since an older individual will have more cell cycles in their lifetime and, consequently, increased cancer incidence.

It has been long-established that mouse chromosomes bear telomeres an order of magnitude longer than their human counterparts [22], and perhaps the elongation process in mouse takes more cell cycles simply because the telomeres are much longer.

A study of the gene expression profiles of activated cells in HIV+ and HIV- donors showed significant differences in activated cells in HIV-infected and HIV negative donors [ 34], with activated cells from HIV+ donors expressing many more cell cycle-associated and interferon-stimulated genes than activated cells from HIV negative donors [ 34].

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