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These data suggest that Zip4 expression enhances cell cycle in Hepa cells.
In this regard, our data show for the first time that leptin enhances cell cycle progression in GAS muscle by increasing the activity of the positive regulators of the cell cycle cyclin D1 and PCNA, and by simultaneously decreasing p27Kip1.
Long-term exposure to 2DG enhances cell cycle arrest.
Pim1 enhances cell cycle progression by phosphorylating Cdc25A, Cdc25C, p21cip1, p27kip1 and c-Tak1 [ 2- 5] or by associating with protein complexes required for mitosis [ 6].
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These data provide evidence that leptin may enhance cell cycle progression in the GAS muscle of ob/ob mice.
Mitogenic factors enhance cell cycle progression by increasing the activity of cyclin/CDK complexes, and inducing nuclear to cytoplasmic translocation of these inhibitors of cell cycle progression [23].
Activation of miR-93, miR-98 and miR-197 inhibits expression of FUS1, enhancing cell cycle progression and chemo-resistance in lung cancer cells [12], [13].
The cell cycle machinery is also a prime target for both estrogen and AEs to enhance cell cycle progression or to induce cell cycle arrest, respectively [ 11].
The unaltered apoptotic rate supported the proposition that the increase in cell number was a result of enhance cell cycle kinetics and cellular metabolism rather than increasing viability.
According to this competitive interaction, silencing 7SL increased HuR binding to TP53 mRNA and promoted p53 translation, in turn enhancing cell cycle arrest and senescence [ 14].
In contrast, the related POU4F1/Brn-3a (Brn-3a) blocks p53-mediated apoptosis but co-operates with p53 to enhance cell cycle arrest.
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