Evans blue staining showed that Al treatment induced more cell death in WT than in the mutant (Fig. 2a).
Double Hoechst/PI staining showed that the co-treatment of CD44-PEG-GNCs, PTT, and RT induced significantly more cell death than any other treatment (Fig. 5g).
Smaller nanoparticles with low zeta potential (e.g., those conjugated with arginine) can have such an attribute (i.e., higher electrical field strength), and eventually they cause more cell death.
While K562 cells were cultured with DNR conjugated with PLA/Au nanocomposites, significant morphological changes were detected and more cell death occurred than that of cells treated with DNR alone.
As shown in Fig. 4C, although hTERT overexpression reduced BMP7-induced cell death significantly, BMP7 treatment of GFP-hTERT transformants still showed more cell death than the GFP-hTERT transformants without BMP7 treatment (P = 0.001) (Fig. 4C).
Propidium iodide staining revealed that the TAT-fused, helically stabilized peptide caused more cell death than the TAT-fused eIF4G1 template peptide with substantial decreases in the G1 and G2 cell populations.
The 'light after' PCI treatment was efficient in releasing DOX from the PAMAM-hyd-DOX conjugates, resulted in more nuclear accumulation of DOX and more cell death through synergistic effects.
OHAs in concentration lower than 20 mg/l did not significantly affect cell viability, while OHAs over 40 mg/l reduced cell viability with more cell apoptosis, more cell death, delayed cell cycle and reduced cell proliferation.
The reduction in the anti-apoptotic activity reduces the robustness of the transformed cells and results in more cell death.
Our study showed that macrophage cell death induced by rough Brucella was dose-dependent since more cell death was observed with higher MOIs (Table 1, Figure 3).
Although the percentage of proliferating tumor cells (i.e. Ki-67+) did not appear altered, there was noticeably more cell death (i.e. TUNEL+ cells; Figure 1B) and ESA+CD44+ cells were more frequent in tumors from CPA-treated mice (Figure 1D).
