The more prominent changes in cell cycle controlling proteins found for Hyper-IL-6-treated Colon26 cells would account for the enhanced suppression of proliferation and clonogenicity.
In our study Cal-78 cells are obvious more insensitive to diacerein regarding the cell cycle controls than the SW-1353 cells.
Overlapping or redundant cell cycle controls assure growth arrest.
Furthermore, there is also evidence that FOXM1 cooperates with other cell cycle gene regulators, such as B-myb and E2F, to exert wider and more comprehensive cell cycle control [76 79].
The gene function analysis revealed that BUB1, CCNB1, MYBL2, PKMYT1, RACGAP1, CENPA, ORC6L, TK1, DIAPH3, RFC4, MELK, and RFC4 are associated with one or more functions of cell cycle control, apoptosis or DNA recombination and repair.
In contrast, the pathways most significantly affected by miR-128 transfection are more focused on mitotic-phase cell cycle control and other processes commonly linked with cellular replication [ 38].
Comparatively high number of genes with similar function displayed proportional up- and down-regulation upon paclitaxel treatment, and more specifically, genes related to cell cycle control, metabolism, protein biosynthesis and modification, signal transduction and transport.
More than 20 genes involved in cell cycle control and DNA metabolism were down-regulated by 4-fold or more 24 hr post-IR, implying that there was a common response to IR-induced DNA damage affecting large numbers of genes.
Another indication that suggests a more general RAN-associated function in cell cycle control comes from the observation that RAN may exhibit a dual role, depending on the RAN binding protein RANBP1.
These observations indicate that light and cell cycle controls are more important factors in the patterns of organelle gene expression than the circadian rhythm in C. merolae.
Previous studies on HGF suggest a function of the GINGF3 gene product in cell cycle control, and more specifically, the gene product might directly or indirectly interact with SOS1.
