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If, at a later stage, a gene and its corresponding protein product are determined to have a biochemically characterized molecular function, such as an enzyme or a structural component (subunit) of a macromolecular complex, the protein should be assigned a synonym consistent with the enzyme nomenclature recommended by the IUPAC Enzyme Commission or the macromolecule name adapted by the IUBMB [4].
The target genes for the differentially expressed miRNA include genes of various molecular function such as metal ion binding, sodium-potassium ion, transcription factors, which may play key role in reducing I/R injury.
Moreover, 17 837 sequences showed potential molecular function, such as binding (13 027; 73%), catalytic activity (8473; 47.5%), molecular transducer activity (1648; 9.2%) and transporter activity (1406; 7.8%).
Only eight terms for "molecular function", such as "cofactor binding" and "heme binding and tetrapyrrole binding", were found in the down-regulated genes in TW vs OW (Additional file 5).
PAINT curators chose to propagate fewer annotations that those transferred by Compara, especially those thought to be several steps downstream from the known molecular function, such as 'negative regulation of neuron apoptosis and spermatogenesis'.
Additional genes were determined to serve in transporter activities such as plasma membrane intrinsic proteins, structural molecule activity such as 50s ribosomal protein l15, and unknown molecular function, such as growth-regulating factor 1, among others.
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Except for biological processes, functional enrichments analysis implies that some molecular functions, such as cytosol, steroid hydroxylase activity, and oxidoreductase activity, also have important impacts on OLPs.
Functional enrichment in large gene families included broad molecular functions such as protein kinase activity, transferase and phosphotransferase activity, binding, catalytic activity, and signal transduction; response to different stimulus such as response to acids and bacteria; and regulation of different processes such as regulation of cellular processes, meristem growth, and immune response.
PRRs are required for the monitoring of pathogens; therefore, polymorphisms in PRRs may influence molecular functions such as ligand recognition.
Molecular functions such as signal transducer activity and protein kinase cascade activity has also been related with several genes from the sub-network.
The dysregulated genes are involved in many cellular and molecular functions, such as defects in angiogenesis [42], nuclear receptors and local growth factors [2], dysfunction of extracellular matrix [43] and TGF-β signaling [44].
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