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Exact(8)
These changes were consistent with ion beam damage of the polymer chain and later show molecular changes consistent with mild pyrolysis of the fibres.
Molecular changes consistent with heart failure were evident by QPCR at age 50 weeks in Tnnt2+/−/TGK210Δ relative to Tnnt2+/−/TGWT mice.
Indeed, we found specific molecular changes consistent with increased EMT in the cycling hypoxia-selected F3 subpopulations.
Molecular changes consistent with epithelial-mesenchymal transition (EMT) were observed in oxaliplatin-treated tumor tissues and verified by in vitro experiments.
Another study used oxaliplatin treatment on an orthotopic nude mouse model of human hepatocellular carcinoma, and demonstrated significantly increased metastasis and molecular changes consistent with EMT 31.
Unlike the situation with hepatocytes [ 12], however, the bulk of the Smad2 null IMEC population retained an epithelial morphology in the basal state, although there was some evidence for molecular changes consistent with a partial EMT (see below).
Similar(52)
All of these molecular changes are consistent with those observed following shRNA knockdown.
Taken together, our data suggested that hypoxia induces morphologic and molecular changes that are consistent with EMT.
These results indicate that aberrant NF-κB activation within mammary epithelium can lead to molecular and morphological changes consistent with the earliest stages of breast cancer.
Through these studies, we show that NF-κB activation in the virgin mammary gland can lead to rapid molecular and morphological changes consistent with early mammary tumorigenesis, including hyperproliferation of ductal epithelial cells, filling of ductal lumens, macrophage infiltration, and increased expression and mislocalization of the oncogene Mucin 1 (MUC1).
Some consistent molecular changes have been previously described in functioning thyroid adenomas – TShR and Gs alpha gene mutations – [ 1] as well as in papillary thyroid carcinomas: RET/PTC and trk rearrangement [ 2, 3] and B-RAF mutation [ 4].
Related(18)
molecular alterations consistent
cellular changes consistent
genomic changes consistent
morphological changes consistent
molecular signals consistent
molecular weights consistent
molecular representations consistent
molecular features consistent
molecular events consistent
molecular characteristics consistent
molecular sieves consistent
molecular layers consistent
molecular envelopes consistent
molecular responses consistent
molecular insights consistent
molecular signatures consistent
molecular changes deleterious
morphologic changes consistent
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