Taken together, these data strongly suggested that subgroup 10 and subgroup 7 tumors have molecular characteristics that are consistent with luminal and basal type breast cancers, respectively.
No somatic missense mutation was found in the tumor suppressor gene TP53, which is consistent with molecular characteristics of cervix uteri tumors 30.
PCR analysis indicated that the genome of these isolates contained tdh, tlh, and toxRS/new open reading frame 8 DNA sequences and lacked trh sequences (1, 7 ), which are consistent with molecular characteristics of the pandemic clone O3 K6 (1, 5 – 8 ).
This pattern matched exactly the banding pattern of the donor sheep, and was consistent with the molecular characteristics of other UK atypical scrapie field isolates run on the same gel.
The pathology and molecular characteristics were distinct from classical BSE, and broadly consistent with published data, but with some variation in the pathological characteristics.
The predicted translation product of the S. invicta tranferrin (SiTf) gene was a 702 amino acid polypeptide with an estimated molecular mass of 77.3 kDa and a pI value of 5.66, characteristics consistent with transferrin proteins.
Only a few animals (5 sheep and 2 goats) in this large series of TSE-affected animals showed molecular characteristics that, in comparison with the usual features of scrapie, could be consistent with the known BSE signature in small ruminants.
Nonkeratinizing NPC is a unique epithelial carcinoma in the head and neck region with peculiar histological and molecular characteristics, including intensive infiltration of lymphocytes, undifferentiated or poorly differentiated appearance, absence of p53 mutations, and consistent association with EBV infection.
Because of the new understanding of tumors at the molecular level, some experts predicted that cancers would soon be classified by their molecular characteristics rather than the anatomical site of origin as is current practice.
But that is work done mainly by looking at the molecular characteristics of the cells, not by trying the cells in animals.
