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These results provide molecular insights consistent with the anti-HIV mechanisms of GAP31 in its inhibition on the integration of viral DNA into the host genome by HIV-integrase as well as irreversible topological relaxation of the supercoiled viral DNA.
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Moreover, molecular insights of most of these traits are not yet clearly understood.
Our studies provide some new molecular insights into this process.
Taken together, observations from this integrated approach are consistent with what is known about the TCR pathway, demonstrating the power of a multi-omics dataset to gain comprehensive molecular insights.
Neuroimaging can also provide molecular insights into treatment mechanism.
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