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Caspase-2 inside mitochondria is activated in response to injury and can lead to nuclear morphological changes consistent with apoptosis in a cell free model18.
Specifically, treatment on gestational day 17 (GD17) has proven to produce morphological changes consistent with findings in schizophrenia (Moore and Grace, 1997; Flagstad et al, 2004), as well as behavioral changes mimicking the positive and negative symptoms of the disorder (Flagstad et al, 2004).
Cell staining with Hoechst-33342 showed morphological changes consistent with both necrotic and apoptotic death sequences, depending upon the presence of oxygen.
This was accompanied by electrophysiological and morphological changes consistent with the generation of "silent synapses," which provide an ideal substrate for further experience-dependent modifications of neural circuitry and which may also be important for the consolidation of long-term synaptic plasticity and memories.
As shown in Fig. 3A, incubation of cells with reduced glucose concentrations resulted in morphological changes consistent with reduced cell viability (Fig. 3B and C).
An intriguing indication of the antiquity of the disease is the finding of non-specific morphological changes consistent with tuberculosis in a fossil Homo erectus dating from the middle Pleistocene (490 510,000 years BP) from Turkey [18].
Similar(32)
Protease treatment results in an initial swelling of the ZP, a morphological change consistent with the ZP appearance of the dead embryos recovered from cKO oviducts.
Morphological changes consisting in enlarged ducts, dilated acini and thinner epithelial walls consistent with abnormal mucus plugs were identified in salivary glands from CF patients.
Such morphological changes were consistent with higher mRNA expression level for neural-specific markers.
We next evaluated whether these morphological changes were consistent with EMT.
Taken together, these biomarker changes, accompanied by pulmonary morphological changes, are consistent with development of human BPD.
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