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Based on these findings, we hypothesized that modulation of arterial baroreflex function by somatic afferents is mediated by NK1-R dependent inhibition of barosensitive NTS circuits.
Euglycemic clamp studies revealed that insulin rather than glucose is the main determinant of arterial stiffness in the postprandial state (24), and the kinetics of the postprandial insulin release might have an impact on the modulation of arterial stiffness.
We used mice with targeted disruption of the 11β-HSD1 gene (Hsd11b1) to investigate the hypothesis that 11β-HSD1 metabolises 7-oxysterols in the arterial wall, thus influencing 7-KC and 7βOHC-mediated modulation of arterial function.
Added to these four well-known causes of hypoxemia is the also well-known modulation of arterial oxygenation by so-called extra-pulmonary factors: O2 consumption, ventilation, cardiac output, acid/base state, HbP50 and concentration, and body temperature [ 4].
While their vasculoprotective properties were at first attributed to their activity as antioxidants in vitro [4], recent research has shown that this is unlikely [5] and that the modulation of arterial function of flavan-3-ols is based on a nitric oxide-dependent mechanism [6 8].
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Thus, chronic exposure to estrogen positively alters cerebrovascular function, at least in younger F. Interestingly, there appear to be striking sex-differences in the modulation of cerebrovascular arterial tone, with M arteries exhibiting greater myogenic tone in response to increasing pressure as compared to F [ 2].
The autonomic nervous system serves as the main regulator of blood pressure and heart rate homeostasis, in part, by modulation of the arterial baroreflex [4].
Physiologically, the changes in MAP are dissociated from the changes in cardiac output because of the sympathetic modulation of the arterial tone, which tends to maintain MAP constant while cardiac output varies.
Today it is known that the endothelium produces various substances collectively termed endothelium-derived relaxing factors (EDRFs) and endothelium-derived constricting factors (EDCFs), based on their function in modulation of the arterial wall.
During BW, mean arterial pressure (CO × TPR) and pulse arterial pressure (SV/C) were maintained at the expense of a CO and SV decrease, secondary to a 45% increase of TPR and 14% decrease of C, probable due to the sympathetic modulation of the arterial tone.
The cardiovascular system provides adequate pressure and flow to the peripheral organs in different physiological (rest and exercise) and pathological conditions because of the continuous modulation of the arterial system compliance, stiffness and resistance with respect to left ventricular (LV) systolic performance [ 2].
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