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It seems clear that therapies modulating a single target yield nothing but minor alteration of a diseases complex machinery.
By lengthening the contraction region in the CEA microchannel, we can easily control the lateral migration of desired particles by modulating a single force component (inertial lift force) without affecting the other (Dean drag force).
The first one involves modulating a single carrier over the full bandwidth B (MIMO-SC), whereas the second approach converts the frequency selective channel into a set of multiple parallel flat fading channels in the frequency domain.
However, it seems unlikely that modulating a single target will provide an effective therapy; in addition, given the ubiquity of these targets and their functions in a very broad range of cell types it may be anticipated that adverse effects will limit their utility.
The complexity of the metabolic process due to the multiple proteins modulating a single reaction often refers to the functional redundancy and mutual participation scenarios.
In hypertension, the etiology of BP elevation is usually multifactorial, making it unlikely that BP control can be achieved by modulating a single mechanism [ 4, 25].
Similar(53)
We use binary amplitude modulation (BAM) to modulate a single bit on each subchannel.
One of the most effective approaches to redirect alternative splicing events has been to attach cell-penetrating peptides to oligonucleotides that can modulate a single splicing event and restore correct gene expression.
A limitation of animal models is they cannot be used to elucidate the mechanisms by which sepsis can modulate a single cell type, such as the alveolar epithelium.
However, single drug approaches modulating an individual arm of the immune system are often incompletely effective.
Depending on the time point chosen, from 217 to 735 genes were significantly modulated at any single time point and between 3 and 194 genes were specifically modulated during a single time point.
Related(20)
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modulating a GLI1/Bcl-2/BAX
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modulating a specific
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modulating a continuous
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modulating a whole
modulating a β-associated
modulating a eukaryotic-type
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