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Particularly, experiments on mouse models revealed indispensible functions of HSPG in modulating A β-associated neuroinflammation and clearance of A β from the brain.
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Hence, it is possible that HSPs modulate A β, tau, and HTT toxicity through interactions with Akt.
This paper shows that NBPF1 can exert its tumor suppressive effect in different ways: by blocking cell division, inducing cell death, or by modulating a cancer-associated proteome.
Smad7 is a key negative regulator of the transforming growth factor β (TGF-β) signaling and plays an important role in modulating a large array of biological processes.
Transcriptionally active β-catenin therefore modulates a plethora of downstream biological processes, including pluripotency, EMT, oxidative stress and lineage commitment.
We have generated a β-sheet associated β-strand pattern that may be important for protein structure prediction and modeling.
Instead, Kaiso binds TCF, a β-catenin-associated transcription factor.
One possible explanation is that acute Wnt/β-catenin signalling could modulate a downstream component of Notch.
(A ) Simplified model of sensory inputs modulating TGF-β and insulin signaling in the regulation of the dauer decision.
Here, we report an important role of BRCA1 in modulating TGF-β signaling during oxidative stress responses.
Modulating the β-adrenergic system, and in particular β blockade, is therefore an exciting new therapeutic approach.
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