Sentence examples for modulate insulin action from inspiring English sources

Interestingly a novel HN analog termed HNGF6A, which we created by combining both changes at position 6 and 14, dramatically increases its ability to modulate insulin action and offers a mode of administration that is more clinically applicable.

Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis.

Additionally, AASs improved insulin sensitivity, mainly when associated with RT, short-term RT alone caused minor effects on glucose homeostasis, and AASs appeared to modulate insulin action.

We speculate that down regulation of Munc18c presents a mode of regulation that may serve as a compensatory mechanism to facilitate GLUT4 translocation and modulate insulin action.

It is now well established that a number of circulating hormones, cytokines, and metabolic fuels, such as non-esterified fatty acids (NEFAs), are being released by adipose tissue and can modulate insulin action.

Dandona et al. noted that increased concentrations of TNFα and IL-6 in type 2 diabetes may modulate insulin action by suppressing insulin signal transduction and this may "shift" the effects of insulin to favor a more proinflammatory state [ 48].

One such target is insulin receptor substrate 1 (IRS-1) serine phosphorylation which is mediated by inflammatory kinases such as c-Jun N-terminal kinase (JNK) and IκB kinase beta (IKKβ) and consequently modulates insulin action [17] [19].

It modulates insulin action and exerts anti-inflammatory effects, playing an important role in the pathogenesis of metabolic syndrome [ 16].

Likewise, we show that co-infusion of a STAT-3 inhibitor with HN into the third ventricle completely attenuates the ability of HN to modulate peripheral insulin action.

For example, AAS administration has been reported to increase the transcription and translation of insulin from pancreatic islet cells and to improve insulin action, modulating glucose levels.

Further studies are warranted to thoroughly investigate the long-term effects of bariatric surgery on incretin responses and action to modulate insulin secretion.